Perry-Spruill House, also known as Spruill House, is a historic home located at Plymouth, Washington County, North Carolina. It was built between 1882 and 1884, and is a 1 1/2-story, three bay, Gothic Revival style frame cottage. It has a high hipped roof with intersecting cross gables ornamented with inverted fleur-de-lys sawnwork, a full-width front porch, pointed Gothic windows, and is sheathed in weatherboard.