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Istres (French pronunciation: ​[istʁ]) (Occitan: Istre) is a commune in southern France, some 60 km (38 mi) northwest of Marseille. It is in the Provence-Alpes-Côte d'Azur region, in the Bouches-du-Rhône department, of which it is a subprefecture.

The arrondissement of Istres is an arrondissement of France in the Bouches-du-Rhône department in the Provence-Alpes-Côte d'Azur region. It has 21 communes. Its population is 327,971 (2016), and its area is 715.2 km2 (276.1 sq mi).