Midtown to Canyon Start

The D.C. Booth Historic National Fish Hatchery and Archives, also known as the Spearfish Fisheries Center or Spearfish Fisheries Complex and formerly known as the Spearfish National Fish Hatchery, is one of 70 fish hatcheries that were opened by the U.S. Fish and Wildlife Service as part of the National Fish Hatchery System.

Black Hills State University (BHSU) is a public university in Spearfish, South Dakota. Close to 4,500 students attend classes at its 123-acre (50 ha) campus in Spearfish, at sites in Rapid City and Pierre, and through distance offerings. Enrollment comes from all 66 counties in South Dakota, 44 states, and 29 countries.

The Episcopal Church of All Angels is a historic church at 129 W. Michigan in Spearfish, South Dakota. It was built in 1895 and was added to the National Register in 1976.Before the building of the only Episcopal church in Spearfish, Episcopalian worshippers practiced in their homes. The great-granddaughter of Alexander Hamilton donated money for a church to be built as a tribute to her great-grandfather, although she never visited Spearfish.

The Arthur Hewes House, at 811 St. Joe in Spearfish, South Dakota, was built in 1905. It was listed on the National Register of Historic Places in 1990.It is a two-and-a-half-story wood frame house on a stone foundation. It was deemed notable as "a good example of the Queen Anne style of architecture as popular in Spearfish, South Dakota, during the late 19th and early 20th centuries."Arthur Hewes operated a general store in Spearfish from 1903 to 1921 or later.

The James A. Corbin House, at 345 Main St. in Spearfish, South Dakota, was built in 1918. It was listed on the National Register of Historic Places in 1990.It is a two-story vernacular-style house. Nonetheless it was deemed significant as "a good example of vernacular domestic housing in Spearfish, South Dakota, in the early 20th Century.

Spearfish Canyon is a deep but narrow gorge carved by Spearfish Creek located in Lawrence County, South Dakota, U.S., just south of Spearfish. The canyon is located within the Black Hills, located on the northern edge of the Black Hills National Forest. The Spearfish Canyon Scenic Byway travels through the Canyon from Spearfish to Cheyenne Crossing along U.

The Spearfish Filling Station, located at 706 Main St. in Spearfish, South Dakota, was built in 1923. It was listed on the National Register of Historic Places in 1988.It is a one-story building with five bays: an angled office bay, a shop bay, and three car service bays. It was built by Alfred J. Sheep, a rancher and businessman, as the first gas station in the community, with the service bays added in 1927.