Mandanici (Sicilian: Mannanici) is a comune (municipality) in the Metropolitan City of Messina in the Italian region Sicily, located about 170 kilometres (110 mi) east of Palermo and about 30 kilometres (19 mi) southwest of Messina. Mandanici borders the municipalities of Fiumedinisi, Nizza di Sicilia, Pagliara, Roccalumera, and Santa Lucia del Mela.