Vezzi Portio (Ligurian: Vessi Portio) is a comune (municipality) in the Province of Savona in the Italian region Liguria, located about 50 kilometres (31 mi) southwest of Genoa and about 13 kilometres (8 mi) southwest of Savona. Vezzi Portio borders the following municipalities: Finale Ligure, Noli, Orco Feglino, Quiliano, Spotorno, and Vado Ligure.