Città di Castello (Italian pronunciation: [tʃitˈta ddi kaˈstɛllo]; "Castle Town") is a city and comune in the province of Perugia, in the northern part of the Umbria. It is situated on a slope of the Apennines, on the flood plain along the upper part of the river Tiber. The city is 56 km (35 mi) north of Perugia and 104 km (65 mi) south of Cesena on the motorway SS 3 bis.